He was later appointed as the Founder Vice Chancellor of Mehran University of Engineering &Technology, Jamshoro. He served in this position for next more than 11 years and established it in two campuses at Jamshoro and Nawabshah. He also had the distinction of holding the office of Secretary to Government of Pakistan for over a decade. To develop highly qualified Scientific and Technological Manpower, he brought to fruition and the laying of the foundation of the Institute of Science and Technology of Pakistan, ISATOP renamed as SZABIST. He also got established National Science Research Fund (NCRF) to promote the scientific research in the Universities and R&D organizations. Besides, he got a number of other prestigious institutions and universities established in the country. He has, therefore, the experience of planning , founding, establishing and managing a number of Educational Institutions. As Secretary, Ministry of Science and Technology, Government of Pakistan, appointed by end of 1994, he saw the establishment of COMSATS, which established later the renowned and leading COMSATS Institute of Information Technology (CIIT). He got a high level Committee appointed by the Prime Minister to look into the reforming of the Science and Technology system to meet the contemporary needs of rapid economic development and security. He was elected as Vice Chairman, UN Commission on Science and Technology for Development (UNCSTD) and brought home to the developing countries the themes of developing their potential in the fields of Information Technology, Science and Technology. He, however, retired soon early in 1996.Dr. Qureshi has remained the Chairman and member of Governing bodies of a number of Government and Non-government prestigious organizations and learned bodies. He has also enjoyed a distinction of participating in a number of meetings, workshops, seminars and conferences at national and international forums including those of United Nations like UNESCO, UNCTAD, UNCSTD and ISESCO and COMSTECH of OIC etc. He has also published a number of research papers, reports etc. and has very widely traveled.